Tuberculosis Latency: Host and Pathogen Mechanisms

Date: Januray 1st, 2011

This collection of works represent the latest research and development in this area. You can see the main point of each work by clicking on its title. Furthermore, each work is followed by the PubMed box which is linked to the PubMed database upon clicking so that the abstract and other information regarding the work can be found.

(1)Genome-Wide Screen for Mycobacterium tuberculosis Genes That Regulate Host Immunity. [PubMed]
(2)Polymorphisms of the NRAMP1 gene: Distribution and susceptibility to the development of pulmonary tuberculosis in the Greek population. [PubMed]
(3)Hemolytic phospholipase Rv0183 of Mycobacterium tuberculosis induces inflammatory response and apoptosis in alveolar macrophage RAW264.7 cells. [PubMed]
(4)IL-10 Blocks Phagosome Maturation in Mycobacterium tuberculosis-infected Human Macrophages. [PubMed]
(5)Optimization of inhaled therapies for tuberculosis: The role of macrophages and dendritic cells. [PubMed]
(6)Kinetics and cellular sources of cathelicidin during the course of experimental latent tuberculous infection and progressive pulmonary tuberculosis. [PubMed]
(7)Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice. [PubMed]
(8)Individual Mycobacterium tuberculosis universal stress protein homologues are dispensable in vitro. [PubMed]
(9)Mycobacterium tuberculosis protein kinase K confers survival advantage during early infection in mice and regulates growth in culture and during persistent infection: implications for immune modulation. [PubMed]
(10)DNA repair systems and the pathogenesis of Mycobacterium tuberculosis: varying activities at different stages of infection. [PubMed]
(11)The type I NADH dehydrogenase of Mycobacterium tuberculosis counters phagosomal NOX2 activity to inhibit TNF-alpha-mediated host cell apoptosis. [PubMed]
(12)Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors. [PubMed]
(13)Attenuation of Mycobacterium tuberculosis functionally disrupted in a fatty acyl-coenzyme A synthetase gene fadD5. [PubMed]
(14)Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host. [PubMed]
(15)TNF in host resistance to tuberculosis infection. [PubMed]
(16)Promotion of a down-modulated lung immune state may be a strategy by M. tuberculosis to foster active disease and persistence. [PubMed]
(17)Microscopic cords, a virulence-related characteristic of Mycobacterium tuberculosis, are also present in nonpathogenic mycobacteria. [PubMed]
(18)Revisiting the natural history of tuberculosis. The inclusion of constant reinfection, host tolerance, and damage-response frameworks leads to a better understanding of latent infection and its evolution towards active disease. [PubMed]
(19)Mycobacterium tuberculosis cAMP receptor protein (Rv3676) differs from the Escherichia coli paradigm in its cAMP binding and DNA binding properties and transcription activation properties. [PubMed]
(20)Establishment of a guinea pig model of latent tuberculosis with GFP-introduced Mycobacterium tuberculosis. [PubMed]
(21)Foamy macrophages and the progression of the human tuberculosis granuloma. [PubMed]
(22)Phosphate depletion: a novel trigger for Mycobacterium tuberculosis persistence. [PubMed]
(23)Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response. [PubMed]
(24)Mycobacterium tuberculosis universal stress protein Rv2623 regulates bacillary growth by ATP-Binding: requirement for establishing chronic persistent infection. [PubMed]
(25)Design of immunogenic peptides from Mycobacterium tuberculosis genes expressed during macrophage infection. [PubMed]
(26)New anti-tuberculosis drugs: strategies, sources and new molecules. [PubMed]
(27)Protection of Mycobacterium tuberculosis from reactive oxygen species conferred by the mel2 locus impacts persistence and dissemination. [PubMed]
(28)Acute and persistent Mycobacterium tuberculosis infections depend on the thiol peroxidase TpX. [PubMed]
(29)Tuberculosis complicating imatinib treatment for chronic myeloid leukaemia. [PubMed]
(30)Inhibition of MptpB phosphatase from Mycobacterium tuberculosis impairs mycobacterial survival in macrophages. [PubMed]
(31)Reaction of Mycobacterium tuberculosis cytochrome P450 enzymes with nitric oxide. [PubMed]
(32)Mycobacterium tuberculosis infection of human monocyte-derived macrophages leads to apoptosis of T cells. [PubMed]
(33)Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles. [PubMed]
(34)Characterization of Mce4A protein of Mycobacterium tuberculosis: role in invasion and survival. [PubMed]
(35)Differentially expressed genes in Mycobacterium tuberculosis H37Rv under mild acidic and hypoxic conditions. [PubMed]
(36)Trehalose 6,6'-dimycolate on the surface of Mycobacterium tuberculosis modulates surface marker expression for antigen presentation and costimulation in murine macrophages. [PubMed]
(37)Foamy macrophages from tuberculous patients' granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence. [PubMed]
(38)Signalling inhibitors against Mycobacterium tuberculosis--early days of a new therapeutic concept in tuberculosis. [PubMed]
(39)A comparative study of host response to three Mycobacterium tuberculosis PE_PGRS proteins. [PubMed]
(40)Tumor necrosis factor blockers influence macrophage responses to Mycobacterium tuberculosis. [PubMed]
(41)Capsular glucan and intracellular glycogen of Mycobacterium tuberculosis: biosynthesis and impact on the persistence in mice. [PubMed]
(42)How Mycobacterium tuberculosis subverts host immune responses. [PubMed]
(43)Characterization of T-cell immunogenicity of two PE/PPE proteins of Mycobacterium tuberculosis. [PubMed]
(44)A Mycobacterium tuberculosis Rpf double-knockout strain exhibits profound defects in reactivation from chronic tuberculosis and innate immunity phenotypes. [PubMed]
(45)Functional characterization of the phospholipase C activity of Rv3487c and its localization on the cell wall of Mycobacterium tuberculosis. [PubMed]
(46)Whole genome identification of Mycobacterium tuberculosis vaccine candidates by comprehensive data mining and bioinformatic analyses. [PubMed]
(47)Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli. [PubMed]
(48)Differential fadE28 expression associated with phenotypic virulence of Mycobacterium tuberculosis. [PubMed]
(49)Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection. [PubMed]
(50)Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B. [PubMed]
(51)Proposed management of childhood tuberculosis in low-incidence countries. [PubMed]
(52)Visceral adipose tissue specific persistence of Mycobacterium tuberculosis may be reason for the metabolic syndrome. [PubMed]
(53)Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon. [PubMed]
(54)Responses of Mycobacterium tuberculosis hemoglobin promoters to in vitro and in vivo growth conditions. [PubMed]
(55)The potential role of lung epithelial cells and beta-defensins in experimental latent tuberculosis. [PubMed]
(56)The timing of TNF and IFN-gamma signaling affects macrophage activation strategies during Mycobacterium tuberculosis infection. [PubMed]
(57)Mutation in the transcriptional regulator PhoP contributes to avirulence of Mycobacterium tuberculosis H37Ra strain. [PubMed]
(58)Differential expression of mycobacterial antigen MPT64, apoptosis and inflammatory markers in multinucleated giant cells and epithelioid cells in granulomas caused by Mycobacterium tuberculosis. [PubMed]
(59)Tumor necrosis factor blockade in chronic murine tuberculosis enhances granulomatous inflammation and disorganizes granulomas in the lungs. [PubMed]
(60)Mechanism of product release in NO detoxification from Mycobacterium tuberculosis truncated hemoglobin N. [PubMed]
(61)How a different look at latency can help to develop novel diagnostics and vaccines against tuberculosis. [PubMed]
(62)Mycobacterium tuberculosis 6-kDa early secreted antigenic target (ESAT-6) protein downregulates lipopolysaccharide induced c-myc expression by modulating the extracellular signal regulated kinases 1/2. [PubMed]
(63)Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo. [PubMed]
(64)Abatacept treatment does not exacerbate chronic Mycobacterium tuberculosis infection in mice. [PubMed]
(65)Impaired expression of perforin and granulysin in CD8+ T cells at the site of infection in human chronic pulmonary tuberculosis. [PubMed]
(66)Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells. [PubMed]
(67)The genetic control of susceptibility to Mycobacterium tuberculosis. [PubMed]
(68)Th2 cytokines in susceptibility to tuberculosis. [PubMed]
(69)The PGRS domain of Mycobacterium tuberculosis PE_PGRS Rv1759c antigen is an efficient subunit vaccine to prevent reactivation in a murine model of chronic tuberculosis. [PubMed]
(70)Mechanisms of polymorphonuclear neutrophil-mediated induction of HIV-1 replication in macrophages during pulmonary tuberculosis. [PubMed]
(71)Mycobacterium tuberculosis SigF regulates genes encoding cell wall-associated proteins and directly regulates the transcriptional regulatory gene phoY1. [PubMed]
(72)Host innate immune response to Mycobacterium tuberculosis. [PubMed]
(73)New insights on the nature of latent tuberculosis infection and its treatment. [PubMed]
(74)Immunological protection against mycobacterium tuberculosis infection. [PubMed]
(75)Life and death in the granuloma: immunopathology of tuberculosis. [PubMed]
(76)An in vitro model of the leukocyte interactions associated with granuloma formation in Mycobacterium tuberculosis infection. [PubMed]
(77)Langhans giant cells from M. tuberculosis-induced human granulomas cannot mediate mycobacterial uptake. [PubMed]
(78)Mycobacterium marinum infection of adult zebrafish causes caseating granulomatous tuberculosis and is moderated by adaptive immunity. [PubMed]
(79)A deletion defining a common Asian lineage of Mycobacterium tuberculosis associates with immune subversion. [PubMed]
(80)Modelling the human immune response mechanisms to mycobacterium tuberculosis infection in the lungs. [PubMed]
(81)Vaccine approaches to prevent tuberculosis. [PubMed]
(82)Kinetic modeling of tricarboxylic acid cycle and glyoxylate bypass in Mycobacterium tuberculosis, and its application to assessment of drug targets. [PubMed]
(83)[The role of human dendritic cells in tuberculosis: protector or non-protector?]. [PubMed]
(84)Novel conjugate of moxifloxacin and carboxymethylated glucan with enhanced activity against Mycobacterium tuberculosis. [PubMed]
(85)Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence. [PubMed]
(86)Ligand-induced dynamical regulation of NO conversion in Mycobacterium tuberculosis truncated hemoglobin-N. [PubMed]
(87)Decreased CD4+ lymphocytes and innate immune responses in adults with previous extrapulmonary tuberculosis. [PubMed]
(88)RUTI: a new chance to shorten the treatment of latent tuberculosis infection. [PubMed]
(89)Mycobacterium tuberculosis gene expression profiling within the context of protein networks. [PubMed]
(90)Heparin-binding hemagglutinin, from an extrapulmonary dissemination factor to a powerful diagnostic and protective antigen against tuberculosis. [PubMed]
(91)[Apoptosis of immune system cells in tuberculosis infection]. [PubMed]
(92)Alternative activation deprives macrophages of a coordinated defense program to Mycobacterium tuberculosis. [PubMed]
(93)Increased pathology in lungs of mice after infection with an alpha-crystallin mutant of Mycobacterium tuberculosis: changes in cathepsin proteases and certain cytokines. [PubMed]
(94)Regulation of the Mycobacterium tuberculosis mce1 operon. [PubMed]
(95)[Cell immunity response in human pulmonary tuberculosis. Review]. [PubMed]
(96)Green tea polyphenol inhibits Mycobacterium tuberculosis survival within human macrophages. [PubMed]
(97)Smoking and tuberculosis: the epidemiological association and immunopathogenesis. [PubMed]
(98)The pathogenesis and pathology of bovine tuberculosis with insights from studies of tuberculosis in humans and laboratory animal models. [PubMed]
(99)Persistent replication of human immunodeficiency virus type 1 despite treatment of pulmonary tuberculosis in dually infected subjects. [PubMed]
(100)Immunological control of tuberculosis: role of tumour necrosis factor and more. [PubMed]
(101)DNAzymes targeting the icl gene inhibit ICL expression and decrease Mycobacterium tuberculosis survival in macrophages. [PubMed]
(102)Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase. [PubMed]
(103)Tumor necrosis factor and chemokine interactions in the formation and maintenance of granulomas in tuberculosis. [PubMed]
(104)Bioactivation of latent transforming growth factor beta1 by Mycobacterium tuberculosis in human mononuclear phagocytes. [PubMed]
(105)Effector functions of heparin-binding hemagglutinin-specific CD8+ T lymphocytes in latent human tuberculosis. [PubMed]
(106)Requirement of the mymA operon for appropriate cell wall ultrastructure and persistence of Mycobacterium tuberculosis in the spleens of guinea pigs. [PubMed]
(107)Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages. [PubMed]
(108)Mechanisms of mycobacterial persistence in tuberculosis. [PubMed]
(109)Highly focused T cell responses in latent human pulmonary Mycobacterium tuberculosis infection. [PubMed]
(110)The stress-responsive chaperone alpha-crystallin 2 is required for pathogenesis of Mycobacterium tuberculosis. [PubMed]
(111)Morphometric analysis of Th(1) and Th(2) cytokine expression in human pulmonary tuberculosis. [PubMed]
(112)Prolonged toll-like receptor signaling by Mycobacterium tuberculosis and its 19-kilodalton lipoprotein inhibits gamma interferon-induced regulation of selected genes in macrophages. [PubMed]
(113)Identifying control mechanisms of granuloma formation during M. tuberculosis infection using an agent-based model. [PubMed]
(114)Cell biology of mycobacterium tuberculosis phagosome. [PubMed]
(115)IL-10 down-regulates costimulatory molecules on Mycobacterium tuberculosis-pulsed macrophages and impairs the lytic activity of CD4 and CD8 CTL in tuberculosis patients. [PubMed]
(116)Transactivation of human immunodeficiency virus-1 in T-cells by Mycobacterium tuberculosis-infected mononuclear phagocytes. [PubMed]
(117)Induction of a novel class of diacylglycerol acyltransferases and triacylglycerol accumulation in Mycobacterium tuberculosis as it goes into a dormancy-like state in culture. [PubMed]
(118)Dendritic cell trafficking and antigen presentation in the human immune response to Mycobacterium tuberculosis. [PubMed]
(119)A study of the safety, immunology, virology, and microbiology of adjunctive etanercept in HIV-1-associated tuberculosis. [PubMed]
(120)The immunological aspects of latency in tuberculosis. [PubMed]
(121)Immunology of tuberculosis and implications in vaccine development. [PubMed]
(122)Hypervirulent mutant of Mycobacterium tuberculosis resulting from disruption of the mce1 operon. [PubMed]
(123)Deletion of Mycobacterium tuberculosis sigma factor E results in delayed time to death with bacterial persistence in the lungs of aerosol-infected mice. [PubMed]
(124)Functional analysis of the Mycobacterium tuberculosis MprAB two-component signal transduction system. [PubMed]
(125)The potential of human neutrophil peptides in tuberculosis therapy. [PubMed]
(126)Survival perspectives from the world's most successful pathogen, Mycobacterium tuberculosis. [PubMed]
(127)Reactivation of latent tuberculosis infection in TNF-deficient mice. [PubMed]
(128)Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program. [PubMed]
(129)Sulfolipid deficiency does not affect the virulence of Mycobacterium tuberculosis H37Rv in mice and guinea pigs. [PubMed]
(130)The Mycobacterium tuberculosis 19-kilodalton lipoprotein inhibits gamma interferon-regulated HLA-DR and Fc gamma R1 on human macrophages through Toll-like receptor 2. [PubMed]
(131)How is the phagocyte lectin keyboard played? Master class lesson by Mycobacterium tuberculosis. [PubMed]
(132)Deficiency in mycolipenate- and mycosanoate-derived acyltrehaloses enhances early interactions of Mycobacterium tuberculosis with host cells. [PubMed]
(133)Human immunity to M. tuberculosis: T cell subsets and antigen processing. [PubMed]
(134)Molecular mechanisms regulating persistent Mycobacterium tuberculosis infection. [PubMed]
(135)DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells. [PubMed]
(136)Expression of Th1-mediated immunity in mouse lungs induces a Mycobacterium tuberculosis transcription pattern characteristic of nonreplicating persistence. [PubMed]
(137)In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice. [PubMed]
(138)Impact of tuberculosis on HIV-1 replication, diversity, and disease progression. [PubMed]
(139)Mycobacterium tuberculosis subverts the differentiation of human monocytes into dendritic cells. [PubMed]
(140)In situ detection of Mycobacterium tuberculosis transcripts in human lung granulomas reveals differential gene expression in necrotic lesions. [PubMed]
(141)Oxidative stress response genes in Mycobacterium tuberculosis: role of ahpC in resistance to peroxynitrite and stage-specific survival in macrophages. [PubMed]
(142)Immunological and pathological comparative analysis between experimental latent tuberculous infection and progressive pulmonary tuberculosis. [PubMed]
(143)Local role for tumor necrosis factor alpha in the pulmonary inflammatory response to Mycobacterium tuberculosis infection. [PubMed]
(144)Inhalable microparticles containing drug combinations to target alveolar macrophages for treatment of pulmonary tuberculosis. [PubMed]
(145)Monocytes/macrophages in HIV infection and tuberculosis. [PubMed]
(146)Recent advances in our understanding of human host responses to tuberculosis. [PubMed]
(147)Mycobacterium tuberculosis signal transduction system required for persistent infections. [PubMed]
(148)CD85/LIR-1/ILT2 and CD152 (cytotoxic T lymphocyte antigen 4) inhibitory molecules down-regulate the cytolytic activity of human CD4+ T-cell clones specific for Mycobacterium tuberculosis. [PubMed]
(149)Nonreplicating persistence of mycobacterium tuberculosis. [PubMed]
(150)Role of trehalose dimycolate in recruitment of cells and modulation of production of cytokines and NO in tuberculosis. [PubMed]
(151)Mycobacterium tuberculosis hemoglobin N displays a protein tunnel suited for O2 diffusion to the heme. [PubMed]
(152)An essential role for phoP in Mycobacterium tuberculosis virulence. [PubMed]
(153)Regulation of virulence genes in Mycobacterium tuberculosis. [PubMed]
(154)M. tuberculosis: immunology and vaccination. [PubMed]
(155)Overexpression of heat-shock proteins reduces survival of Mycobacterium tuberculosis in the chronic phase of infection. [PubMed]
(156)Advances in the immunopathogenesis of pulmonary tuberculosis. [PubMed]
(157)The inflammatory response in Mycobacterium tuberculosis infection. [PubMed]
(158)Persistence of DNA from Mycobacterium tuberculosis in superficially normal lung tissue during latent infection. [PubMed]
(159)A model to predict cell-mediated immune regulatory mechanisms during human infection with Mycobacterium tuberculosis. [PubMed]
(160)Naive human T cells develop into Th1 effectors after stimulation with Mycobacterium tuberculosis-infected macrophages or recombinant Ag85 proteins. [PubMed]
(161)Hypersusceptibility of A/J mice to tuberculosis is in part due to a deficiency of the fifth complement component (C5). [PubMed]
(162)Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase. [PubMed]
(163)Depletion of CD4(+) T cells causes reactivation of murine persistent tuberculosis despite continued expression of interferon gamma and nitric oxide synthase 2. [PubMed]
(164)Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis. [PubMed]
(165)Evolution of granulomas in lungs of mice infected aerogenically with Mycobacterium tuberculosis. [PubMed]
(166)Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate. [PubMed]
(167)Enhancement of immunocompetence in tuberculosis by DNA vaccination. [PubMed]
(168)A mouse model for slowly progressive primary tuberculosis. [PubMed]
(169)Persistence and protective efficacy of a Mycobacterium tuberculosis auxotroph vaccine. [PubMed]
(170)Live antigen carriers as tools for improved anti-tuberculosis vaccines. [PubMed]
(171)The effects of androstenediol and dehydroepiandrosterone on the course and cytokine profile of tuberculosis in BALB/c mice. [PubMed]
(172)The 16-kDa alpha-crystallin (Acr) protein of Mycobacterium tuberculosis is required for growth in macrophages. [PubMed]
(173)Mannose binding protein deficiency is not associated with malaria, hepatitis B carriage nor tuberculosis in Africans. [PubMed]
(174)Activation of latent HIV-1 by Mycobacterium tuberculosis and its purified protein derivative in alveolar macrophages from HIV-infected individuals in vitro. [PubMed]
(175)Seasonality of tuberculosis: the reverse of other respiratory diseases in the UK. [PubMed]
(176)Growth of Mycobacterium tuberculosis in BCG-resistant and -susceptible mice: establishment of latency and reactivation. [PubMed]
(177)Influence of dietary (n-3)-polyunsaturated fatty acids on leukotriene B4 and prostaglandin E2 synthesis and course of experimental tuberculosis in guinea pigs. [PubMed]
(178)Structural features of the exocellular polysaccharides of Mycobacterium tuberculosis. [PubMed]
(179)Influence of tuberculosis on human immunodeficiency virus (HIV-1): enhanced cytokine expression and elevated beta 2-microglobulin in HIV-1-associated tuberculosis. [PubMed]
(180)[Changes in the granuloma in the experimental treatment of tuberculosis with a prolonged form of isoniazid]. [PubMed]
(181)Lipoarabinomannan, a possible virulence factor involved in persistence of Mycobacterium tuberculosis within macrophages. [PubMed]
(182)Vitamin D metabolism in tuberculosis. Production of 1,25(OH)2D3 by cells recovered by bronchoalveolar lavage and the role of this metabolite in calcium homeostasis. [PubMed]
(183)Histochemical demonstration of mycobacterial antigen, specific antibody and complement in the lesions of tuberculosis. [PubMed]
(184)Lack of neutralizing antibodies to caprine arthritis-encephalitis lentivirus in persistently infected goats can be overcome by immunization with inactivated Mycobacterium tuberculosis. [PubMed]
(185)Comparison between immunopotency tests and specific active or passive acquired resistance against Mycobacterium tuberculosis in mice induced with three different preparations of BCG pasteur vaccine. [PubMed]